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Localization of the three major salivary glands. Mucous labial glands.

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Presentatie over: "Localization of the three major salivary glands. Mucous labial glands."— Transcript van de presentatie:

1 Localization of the three major salivary glands

2 Mucous labial glands

3 Functions of saliva in relation to its components

4 30 June 2005 Speekselonderzoek: in de loop der tijd van grof naar fijn; van groot naar klein Opsporing van Functionele Domeinen 1969. Grootste moleculen: Mucinen: MUC5B: 6000 aminozuren 1990: Agglutinine: 2400 aminozuren, naar 11 aminozuren 1995: MUC7: 14 aminozuren? 1995: Histatinen: van 37 naar 14 aminozuren 2000: Cathelicidine: van 170 naar LL-37: 37 aminozuren, naar 25 2000: Lactoferrine: van 700 naar 25, naar 11 aminozuren 2006: bPRPs: van 210 naar 5 aminozuren: Q R F S R: Opiorphin

5 TEETH FOOD Remineralisation Buffering Digestion Taste Bolus Anti-viral Lubrication Anti- bacterial Anti- fungal Mucins Inhibition of demineralization Mucins Functions of saliva Mucins M ICROBES

6 Electron micrograph of MUC5B and MUC7 MUC5B MUC7 by courtesy of JK Sheehan, Manchester, UK 200 nm

7 water MUC5B (MG1) 100 nm MUC7 (MG2) 10 nm SALIVARY MUCINS HS

8 Visco-elasticity of glandular salivas

9 Xialine - based on xanthan gum - commercially available in: The Netherlands - Belgium - Luxembourg Turkey - France (?) New development - antimicrobial activity, based on histatin-analogues Van der Reijden c.s. Arthr. Rheum 39, (1996) 57- 63 Ruissen c.s. Archs Oral Biol. 47, (2002)749-756 Ontwikkeling Speekselsubstituut i.s.m. Prof. Arjan Vissink, Groningen


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