Nieuwe inzichten en behandelingen bij IBD Dr Peter Bossuyt Gastroenterologie IBD kliniek Bonheiden
Hetzelfde maar anders Anders en beter Wat nu? Optimalisatie van de behandeling Anders en beter Nieuwe behandelingen
Hetzelfde maar anders 5-ASA Steroiden Purine-analogen Single dose versus split dose Steroiden “lokaal” werkende versus systemische steroiden Purine-analogen Imuran versus Puri-Nethol
Hetzelfde maar anders Anti-TNF (remicade & humira) Mono versus combo Antistof vorming Effectiviteit Duur? Vroeg- versus laattijdig
Hetzelfde maar anders Anti-TNF (remicade & humira) Through levels
Pre-clinic Phase I Phase II Phase III Launch Type: Biologicals Cytokine/chemokine Hematopoietic stem cell transpl/ (ASTic) Adhesion molecules ABT-874/J695/ Abbott Anti-TNF B Lymphocytes Visilizumab/Nuvion N1-0401-01/ NovImmune T Lymphocytes Abatacept/ Bristol-Mayers Others VT-214/ Viron rIL18 BP/ Merck Serono PF-00547,659 Rituximab/Roche Certolizumab Celltech-UCB AntiCD103/ LigoCyte Opebacan/Xoma Adalimumab/ Abbott Ch5D12/Tanox Basiliximab/ Cerimon Tocilizumab (atlizumab)/Chugai Infliximab/ Centocor/MSD Thymosin beta4/ RegeneRx AntiVAP1/BioTie Vedolizumab (MLN0002)/ Millenium MDX-1100/ Medarex AIN457/novartis Natalizumab/ Elan/Biogen Ustekinumab (CNTO 1275)/ Centocor HuMxIL15/Genmab rhuMab beta7/Genentech C326/Avidia Pre-clinic Phase I Phase II Phase III Launch smad7/ Giuliani THC:CBD/GW Pharmaceuticals CCX282-B / ChemoCentryx IPL42/ Inflazyme NV52/ Novogen Apilimod mesylate (STA5236)/Syntha Revlimid/Celgene Guanilib/Callisto CP-690,550/Pfizer Small molecules Laquinimod Theva
Anders en beter Anti-adhesie CCX282-B Chemocentryx CCR9 Slow down roll Integrines become activated tethering diapedesis chemokine- receptor chemokines a4b7-integrin L-selectin MadCAM-1 CCX282-B Chemocentryx CCR9 Natalizumab (Antegren), Vedolizumab (Millennium), PF-00547659 MadCam, rhuMab-beta7 Genentech, human a4b7 Amgen
Anders en beter Anti-inflammatoir
Anders en beter Stam cell transplantatie endoxan endoxan endoxan L R Cyclo ATG Infusion Conditioning L R G-CSF Pre-mobilisation Phase Mobilisation Phase Post-mobilisation Phase Conditioning and Transplantation Phase Group A Year 1 Conditioning and Transplantation Phase Group B Year 2 PM28 M0 (days) T52 M12 PM0 PM34 T0 (weeks) T54 T106 M6 Stam cell transplantatie endoxan endoxan endoxan
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