A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo Martijn Verdoes, Bogdan I. Florea, Victoria Menendez-Benito,

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1 A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo Martijn Verdoes, Bogdan I. Florea, Victoria Menendez-Benito, Christa J. Maynard, Martin D. Witte, Wouter A. van der Linden, Adrianus M.C.H. van den Nieuwendijk, Tanja Hofmann, Celia R. Berkers, Fijs W.B. van Leeuwen, Tom A. Groothuis, Michiel A. Leeuwenburgh, Huib Ovaa, Jacques J. Neefjes, Dmitri V. Filippov, Gijs A. van der Marel, Nico P. Dantuma, Herman S. Overkleeft Chemistry & Biology Volume 13, Issue 11, Pages 1217-1226 (November 2006) DOI: 10.1016/j.chembiol.2006.09.013 Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

2 Figure 1 Chemistry & Biology 2006 13, 1217-1226DOI: (10.1016/j.chembiol.2006.09.013) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

3 Figure 2 Chemistry & Biology 2006 13, 1217-1226DOI: (10.1016/j.chembiol.2006.09.013) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

4 Figure 3 Chemistry & Biology 2006 13, 1217-1226DOI: (10.1016/j.chembiol.2006.09.013) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

5 Figure 4 Chemistry & Biology 2006 13, 1217-1226DOI: (10.1016/j.chembiol.2006.09.013) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

6 Figure 5 Chemistry & Biology 2006 13, 1217-1226DOI: (10.1016/j.chembiol.2006.09.013) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

7 Figure 6 Chemistry & Biology 2006 13, 1217-1226DOI: (10.1016/j.chembiol.2006.09.013) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions